Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes
Article Abstract:
The incorporation of labeled amino acids into polypeptides during sperm capacitation, which was completely inhibited by mitochondrial translation inhibitors but not by the cytoplasmic translation inhibitors, is demonstrated. The ability of spermatozoa to synthesize proteins, including nuclear-encoded proteins by 55S ribosomal machinery is critical for the final maturation step leading to successful fertilization.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
Article Abstract:
Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC) and that Notch3 is required for arterial specification of vSMC but not of endothelial cells. The data from observation on Notch3 mice reveal Notch3 to be first cell-autonomous regulator of arterial differentiation and maturation of vSMC.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells
Article Abstract:
Studies show that Beta/Beta mice lived longer and had higher energy expenditure than their control littermates due to elevated White Adipose Tissue (WAT) energy oxidation. The WAT of Beta/Beta mice were enriched with metabolically active, thermogenic mitochondria known for energy dissipation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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