Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Article Abstract:

x study was conducted to investigate the effects of a nuclear receptor coactivator known as PCG-1 on a thermogenic program in muscle cells where uncoupling protein-1 (UCP-1) is not present. PGC-1 was found to activate several aspects of the adaptive thermogenic program and has no overall sequence similarity to any known molecules, but contains SR domains and an RNA-binding motif characteristic of splicing factors. Findings indicate that a pathway directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function.

Mitochondria, Tissue respiration

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

Article Abstract:

Research was conducted to test whether PGC-1 nuclear cell receptor plays an important role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis. Amino acids were cloned in-frame into the DNA-binding domain plasmid pAS2 while an expression plasmid for full-length PGC-1 was established by ligating an entire cDNA as a Smal-Xhol fragment. Results indicated that nuclear cell receptors control a range of physiological processes in metazoan organisms.

Cell receptors

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C-fos is required for malignant progression of skin tumors

Article Abstract:

Experiments on the proto-oncogene c-fos of mice with v-H-ras expressing keratinocytes grafted on nude mice reveals that c-fos deficient tumors fail to initiate malignant progression hindering tumorigenesis. The results may be significant for the therapeutic prevention of neoplastic diseases and may point out that the c-fos represents a potential target for pharmacological interventions.

Analysis, Observations, Mice as laboratory animals, House mouse, Skin tumors, Tumor proteins

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