Abstracts

Biological sciences

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Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Article Abstract:

A thorough analysis of the expression and function of the cytosolic Hsp70 proteins in human cancer cells is presented and Hsp70-2, which is a protein essential for spermatogenesis is identified as an important regulator of cancer cell growth. The cancer cells experience a synergistic antiproliferative effect due to the concomitant depletion of the Hsp70 and Hsp70-2, thus demonstrating that the Hsp70 proteins lead to nonoverlapping functions that are essential for cell growth and survival.

Heat shock proteins

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Critical roles for Dicer in the female germline

Article Abstract:

Dicer, an essential component of the ribonucleic acid interference (RNAi) pathways, is necessary to control mouse oocyte gene regulation and genome organization. An examination of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline, essential for turnover of a substantial subset of maternal transcripts normally lost during oocyte maturation.

Science & research, Pennsylvania, Research, Oocytes, Infertility, Female, Female infertility

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Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

Article Abstract:

Normal cell processes when thrown out of gear due to pathological changes, the importance of Dia1, leukemia-associated Rho-GEF and RhoA to normalize the process is presented.

Morphology (Biology), Genetic regulation, Morphology

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