Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

Article Abstract:

A thorough analysis of the expression and function of the cytosolic Hsp70 proteins in human cancer cells is presented and Hsp70-2, which is a protein essential for spermatogenesis is identified as an important regulator of cancer cell growth. The cancer cells experience a synergistic antiproliferative effect due to the concomitant depletion of the Hsp70 and Hsp70-2, thus demonstrating that the Hsp70 proteins lead to nonoverlapping functions that are essential for cell growth and survival.

Heat shock proteins

---

Critical roles for Dicer in the female germline

Article Abstract:

Dicer, an essential component of the ribonucleic acid interference (RNAi) pathways, is necessary to control mouse oocyte gene regulation and genome organization. An examination of tissue-restricted Dicer loss in mice indicates a critical role for Dicer during meiosis in the female germline, essential for turnover of a substantial subset of maternal transcripts normally lost during oocyte maturation.

Science & research, Pennsylvania, Research, Oocytes, Infertility, Female, Female infertility

---

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

Article Abstract:

Normal cell processes when thrown out of gear due to pathological changes, the importance of Dia1, leukemia-associated Rho-GEF and RhoA to normalize the process is presented.

Morphology (Biology), Genetic regulation, Morphology

Similar abstracts:

• Abstracts: Effects of several factors of the heat-shock-induced thermotolerance of Listeria monocytogenes. Cold shock and its effect on ribosomes and thermal tolerance in Listeria monocytogenes
• Abstracts: Optimizing DNA yield from the buccal swabs in the elderly: attempts to promote buccal cell growth in culture
• Abstracts: Generation of pluripotent stem cells from neonatal mouse testis. A contextual model for axonal sorting into glomeruli in the mouse olfactory system
• Abstracts: Molecular genetics of the genus Paracoccus: metabolically versatile bacteria with bioenergetic flexibility. Adaptation and acclimation of photosynthetic microorganisms to permanently cold environments
• Abstracts: Heritabilities and additive genetic variances of the activities of some enzymes in Drosophila melanogaster populations living in different habitats

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.