Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay

Article Abstract:

The chorioallantoic membrane of the developing chick embryo was used as an effective model in the investigation of the mechanisms involved in tumor metastasis particularly tumor intravasation within capillaries. Implanted human tumor cells were shown to metastasize to distant sites connected via blood vessels or lymphatics to the primary site of implantation. It is shown that metalloproteinases are required for tumor intravasation. The metastatic tumor cells are identified using a novel polymerase chain reaction-based technique.

Metastasis, Cancer invasiveness, Cancer metastasis, Metalloenzymes

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

Article Abstract:

Research was conducted to describe similarities between 231 cell-derived vascular endothelial growth factor and human neuropilin-1, a cell-surface glycoprotein associated with axonal guidance in the developing nervous system. Complementary DNA was synthesized from cell mRNA. Results showed a high level of neuropil-1 expression in tumor-derived cells and that an ectopic overexpression of neuropilin-1 resulted in unsuitable vascular endothelial growth factor activities.

Physiological aspects, Glycoproteins, Nervous system, Growth factors, Endothelin

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