Mind the GAP: Wnt steps onto the mTORC1 train

Article Abstract:

The tuberculosis sclerosis complex (TSC)1/2 tumor-suppressor complex controls protein synthesis through the regulation of mTOR. A study reports that mTOR activity is inhibited by the activation of TSC2 in which the kinases glycogen synthase kinase 3 (GSK3) and AMP-activated protein kinase cooperate and that the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signalling.

Sclerosis

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mTOR and S6K1 mediate assembly of the translation initiation complex through dynamic protein interchange and ordered phosphorylation events

Article Abstract:

The mTOR and S6K1 maneuver on and off the eukaryotic initiation factor 3 (elF3) translation initiation complex in a signal-dependent choreographed fashion is studied. The results reveal that the elF3 preinitiation complex acts as a scaffold to coordinate a dynamic sequence of events in response to stimuli that promote efficient protein synthesis.

United States, Genetic translation, Translation (Genetics)

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Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation

Article Abstract:

Studies were conducted to show that Ubp6, one of the enzymes found in yeast proteasomes affects the degradation of a physiological substrate of the proteasome. The findings report that Ubp6 delays the break-down of proteins by the proteasome and that a major component of its inhibitory effect is noncatalytic in nature.

Biodegradation, Ubiquitin-proteasome system

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