Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila
Article Abstract:
The cell fate determinants Numb and Prospero along with prospero RNA are asymmetrically localized in the basal cortex during mitosis by neuroblasts in the Drosophila central nervous system (CNS). The genes inscuteable, miranda and staufen are involved in localization. Miranda protein contains more than one functional domain. Miranda and Staufen exhibit similar patterns of subcellular localization and they interact in vitro. Miranda appears to direct localization in the basal cortex of multiple molecules including Staufen and prospero RNA in mitotic neuroblasts in an actin-dependent manner.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
Article Abstract:
Interferon consensus sequence binding protein (ICSBP)-mutant mice were analyzed to determine the role of ICSBP in the antiviral responses of the immune system and chronic myelogenous leukemia (CML). ICSBP mutants exhibited normal antiviral responses to vesicular stomatitis virus indicating that the interferon, B and T lymphocytic system was not altered by ICSBP- deficiency. However, the mutant mice died after being infected with the lymphocytic choriomeningitis virus. Furthermore, the mutants exhibited hematologic neoplasia that is characteristic of CML.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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