Mismatch repair, molecular switches, and signal transduction
Article Abstract:
Molecular switches in biology, which appear in a controlled form everywhere, are based on translation elongation and cellular signal transduction. Mismatch repair (MMR) has been studied most thoroughly in connection with the DNA adenine methylation (Dam)-instructed pathway in E coli. It seems guanine nucleotides work for cellular signaling and adenine nucleotides work for DNA metabolic signaling, but questions remain. According to the Second Law of Thermodynamics biochemical systems go from one state to another in microsopically reversible steps.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Precise destruction: An emerging picture of the APC
Article Abstract:
A combination of biochemical, genetic and structural approaches is used to study the enzymology of the anaphase-promoting complex (APC), which is an ubiquitin ligase that has a prominent role in regulating cell cycle progression. The advances in the understanding of the TPR (tetratricopeptide repeat) and Cullin arms of the APC, as well as emerging views of the binding relationships between adaptor, APC core and substrate are discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Article Abstract:
Studies show that ceramide levels can control cell survival. Acting as general apoptotic rheostats, ceramides regulate phosphoinositide-3 kinase PI(3)K anti-apoptotic effector mechanisms. Stress-induced ceramide down-regulates PI(3)K activity directly, with effects dependent on dose, with high specificity and rapid kinetics. This decreases the phosphorylation of the Bad death effector.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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