Molecular models for vertebrate limb development
Article Abstract:
Three-dimensional organisms are formed by pattern formation which is conceptualized in secondary fields as occurring in four stages. There is much in interest in developmental biology, in the molecular basis for the four stages, particularly with regard to the developing limb bud in the vertebrate secondary field. Foil barier and extirpation studies have indicated how growth in the limb field could be regulated, such as by intermediate mesoderm. Experimentally induced limb buds form an apical ectodermal ridge (AER) and develop normally. The mechanisms that pattern soft tissues and muscles however, are largely unexplored.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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La Dolce Vita: a molecular feast in plant-pathogen interactions
Article Abstract:
Plant-pathogen interaction is studied to name the resistance proteins (R-proteins) involved in pathogen recognition to be able to identify specific points where pathogens are in the active state in their viral life cycle. Results show that R proteins are composed of Leucine-Rich Repeats (LRRs) which perform protein-protein interaction, peptide-ligand binding and protein-carbohydrate interaction. Another R protein which effectively demonstrates pathogen resistance is the nucleotide-binding site plus leucine-rich repeat (NB-LRR).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Vertebrate left-right development
Article Abstract:
Cell-to-cell signalling mediates the regulation of left-right development in vertebrates. Ectopic expressions in embryos of the members of three significant peptide families, Wnt, Shn, and activin, lead to randomization of left-right asymmetries. The segmental signalling pathway in left-right development of chick embryos by Levin and associates is discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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