Mutations modulating Raf signaling in Drosophila eye development
Article Abstract:
Previous studies have suggested that Raf serine/threonine kinase performs a crucial role in the signal transduction pathways activated by receptor tyrosine kinases. To definitively identify the role played by Raf signaling, an analysis of the dominant mutations that affect the eye development of drosophila was conducted. Forty-four mutations that define eight genes were isolated and analyzed. One mutation identified encoded a mitogen-activated protein kinase homologue while another was identified as the putative target gene of the entire pathway.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1996
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Prevalence of localized rearrangements vs. transpositions among events induced by Drosophila P element transposase on a P transgene
Article Abstract:
The role of P transposase in the recovery of mutations on a P transgene, P[w(superd1)9.3], which contains the whole white gene with 3.44 kb of its 5-prime regulatory sequences duplicated directly in tandem, was determined. The results showed that P transposase induces deletions and amplifications of the original duplicated sequence. These two events occur at different rates.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
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