Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis

Article Abstract:

Gene knockout experiments show that genes that code for the myogenic basic helix-loop-helix proteins have their own unique pattern of expression. Of the four genes, MyoD and Myf-5 have overlapping roles in the generation of myoblasts. Mice double homozygous for null mutations in MyoD and myogenin or Myf-5 and myogenin exhibited embryonic and perinatal phenotypes similar to those observed in mice mutant for each gene alone. These results suggest that the function of myogenin does not overlap with those of MyoD or Myf-5 during embryogenesis.

Genetic aspects, Mice (Rodents), Muscles, Muscle proteins, Myogenesis

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Pax6 is required for delta-catenin/neurojugin expression during retinal, cerebellar and cortical development in mice

Article Abstract:

The regulation of central nervous system through neurojugin expression by paired box gene 6 is analyzed.

Canada, Science & research, Physiological aspects, Retina, Developmental neurology, House mouse

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