TATA element recognition by the TATA box-binding protein has been conserved throughout evolution

Article Abstract:

Results demonstrate interaction and formation of Hoogsteen base pairs between TATA box-binding protein (TBP) and TATA elements in the recognition process. Data also point out that TBP-TATA complex is an integral part of the RNA polymerase II transcription machinery and is conserved through the course of evolution.

Author: Burley, Stephen K., Patikoglou, Georgia A., Kodadek, Thomas, Kim, Joseph L., Sun, Liping, Yang Sang-Hwa
United States, Statistical Data Included, Research, Carrier proteins, Transport proteins, Enzymes, RNA polymerases, Enzyme structure-activity relationships

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Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family

Article Abstract:

The article describes that redundant binding correlates with consensus ETS-binding sequence near transcription start sites and contrary specific binding sites diverged dramatically from the consensus that were found further from transcription sites.

Author: Graves, Barbara J., Hollenhorst, Peter C., Shah, Atul A., Hopkins, Christopher
T cells, DNA-ligand interactions, DNA binding

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Subjects list: Analysis, Genetic transcription, Transcription (Genetics)
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