Narcolepsy: a key role for hypocretins (orexins)

Article Abstract:

Researchers have found a correlation between the hyprocretin (Hcrt) (orexin) peptide system and narcolepsy. Deletions in hypocretin receptor 2 gene were found to be capable of disrupting the membrane transduction or localization function of the Hcrt receptor. Narcolepsy, which is characterized by cataplexy and sleepiness, is a disease that affects about one individual in 2,000. The loss of muscle tone associated with cataplexy is triggered by sudden strong emotions such as anger and laughter.

Cataplexy

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A review of canine inherited bleeding disorders: biochemical and molecular strategies for disease characterization and carrier detection

Article Abstract:

Several inherited bleeding disorders have been determined in dogs that are based on quantitative, functional and structural defects in hemostatic proteins or pathways. Many of the disorders are caused by single-gene defects. Biochemical assay and molecular strategies allow researchers to determine disease phenotype more efficiently. In addition, the methods support the molecular heterogeneity underlying naturally occurring hemostatic defects in canine.

Usage, Biochemical genetics, Molecular genetics

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Genetic studies in narcolepsy, a disorder affecting REM sleep

Article Abstract:

A study was conducted to analyze narcolepsy in canines. Several genomic clones supporting the canarc-1 marker and the variable heavy chain immunoglobulin region were determined in canines. These were partially sequenced and mapped onto specific dog chromosomes using fluorescence in situ hybridization. In addition, the genomic contig is extended using a novel canine BAC library to determine the associated human region of conserved synteny.

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