Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

Article Abstract:

Researchers have been able to identify ACTR, a cofactor which directly binds nuclear receptors and stimulates their transcriptional activities in a hormone-dependent way. This cofactor seems to exert its regulatory effects in two separate biochemical stages. It firstly associates with both CBP/p300 and P/CAF and therefore acts to recruit two transcriptional cofactors to the nuclear receptor-DNA complex. It secondly possesses intrinsic histone acetyltransferase (HAT) activity. It appears that nuclear receptors recruit an enzymatic complex which includes at least three separate classes of mutually interacting HATs.

Hormone receptors, Ligand binding (Biochemistry)

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A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity

Article Abstract:

A study was conducted to examine the mechanism of transcriptional regulation by the protein coactivators, p300/CBP and p300/CBP-associated factor (PCAF) histone acetyltransferases (HATs). Results showed that the adenoviral E1A oncoprotein can inhibit the HAT activity of both p300/CBP and PCAF. The E1A was also found to prevent nucleosomal histone modifications of p53 acetylation. These findings indicate that transcription can be regulated by modulating the HAT activity.

Histones, Genetic transcription, Transcription (Genetics), RNA polymerases, Adenoviruses

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