Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade

Article Abstract:

The localization of Ste5 to the plasma membrane's Gbeta region, essential for pheromone signal transmission to associated MAP kinase cascade enzymes, is shown to require the prior nuclear shuttling of Ste5. The study also reveal that Ste5 that are unable to transit the nucleus are not capable of settling at the periphery and activating the pathway. This regulatory mechanism may help ensure that cytoplasmic Ste5 do not activate downstream kinases and could be applicable to other signaling proteins.

Cells (Biology), Growth, Cells, Cell membranes, Plasma membranes, Pheromones

---

The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites

Article Abstract:

The crystal structure of yeast protein disulfide isomerase reveals that the four thioredoxin domains are arranged in the shape of a twisted 'U' with the active sites facing each other across the long sides of the 'U'. The structure defines a framework for rationalizing the differences between the two active sites and their respective roles in catalyzing the formation and rearrangement of disulfide bonds.

United States, Science & research, Yeast fungi, Yeasts (Fungi), Isomerases, Chemical properties, Thioredoxin

---

Similar abstracts:

• Abstracts: SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis
• Abstracts: Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly
• Abstracts: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
• Abstracts: Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain
• Abstracts: Molecular clocks: The heavy, the cold, and the slow. Evolution within food webs: the possible and the actual. Heritability of progeny size in a terrestrial isopod: Transgenerational environmental effects on a life history trait

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.