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Biological sciences

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Operons in C. elegans: polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions

Article Abstract:

Genes located 100-300 upstream of each of the six Caenorhabditis elegans genes known to be trans-spliced to SL2 were also found to be oriented in the same manner. The genes in these clusters are cotranscribed and downstream mRNAs are formed by cleavage at the polyadenylation site and transplicing. These findings have implications for the mechanism of splicing and polyadenylation and for coordinate regulation of gene expression in C. elegans.

Gene expression, Operons, Caenorhabditis elegans

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mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism

Article Abstract:

Evidence for the direct role of RNA in catalysis of mRNA splicing is accumulating. However, these data may not support an evolutionary relationship between mRNA splicing and group II introns. The spliceosomal small nuclear RNA U2 and U6 have been found to play a catalytic role in mRNA splicing. Similarities between these two classes of molecules have also been noted, but their evolutionary relatedness cannot be well-established.

Introns

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Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets

Article Abstract:

The intracellular distribution patterns in a model of human megakaryocyte differentiation and proplatelet formation are examined. Results reveal the presence of spliceosome components in the cytoplasm of human megakaryocytes and in proplatelets extending from megakaryocytes.

Science & research, Bone marrow cells, Genetic research

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