Origins of the Human Genome Project: Why sequence the human genome when 96% of it is junk?
Article Abstract:
The objections raised to the origin of the Human Genome Project, whereby the idea of sequencing the human genome in order to identify the many oncogenes, tumor suppressors and their modifiers was mooted in 1986, are discussed. The noncoding genome sequences occupying 96% of the DNA sequence, which were thought to be 'junk' and hence worthless to be sequenced, are treated as important tools in gene sequencing since they provide information about genome sequences.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Fine mapping versus replication in whole-genome association studies
Article Abstract:
The comparison of two strategies, 'exact' and 'local' approach to determine the probability of replicating a gene or region under two commonly used marker-selection strategies is presented. The study provides a basis for the design and interpretation of genomewide association (GWA) replication and point to the importance of a clear distinction between fine mapping and replication after GWA.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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So many correlated tests, so little time! Rapid adjustment of 'P' values for multiple correlated tests
Article Abstract:
The method to compute 'P' values for multiple correlated tests which can be applied to genome-wise association (GWA) studies is presented. The Computation is at a greater speed and same accuracy as permutation or simulation-based tests.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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