Origins of the Human Genome Project: Why sequence the human genome when 96% of it is junk?

Article Abstract:

The objections raised to the origin of the Human Genome Project, whereby the idea of sequencing the human genome in order to identify the many oncogenes, tumor suppressors and their modifiers was mooted in 1986, are discussed. The noncoding genome sequences occupying 96% of the DNA sequence, which were thought to be 'junk' and hence worthless to be sequenced, are treated as important tools in gene sequencing since they provide information about genome sequences.

Research and Development in the Physical, Engineering, and Life Sciences, Genetic Engineering, Nucleotide sequencing

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Fine mapping versus replication in whole-genome association studies

Article Abstract:

The comparison of two strategies, 'exact' and 'local' approach to determine the probability of replicating a gene or region under two commonly used marker-selection strategies is presented. The study provides a basis for the design and interpretation of genomewide association (GWA) replication and point to the importance of a clear distinction between fine mapping and replication after GWA.

United States, Comparative analysis, Chromosome mapping, DNA replication, Report

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So many correlated tests, so little time! Rapid adjustment of 'P' values for multiple correlated tests

Article Abstract:

The method to compute 'P' values for multiple correlated tests which can be applied to genome-wise association (GWA) studies is presented. The Computation is at a greater speed and same accuracy as permutation or simulation-based tests.

Statistical hypothesis testing, Permutations

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