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Biological sciences

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Out of the iron age: new insights into the critical role of manganese homeostasis in bacteria

Article Abstract:

Insights into the critical role of manganese homeostasis are discussed relative to bacteria in this review article. New experimental and genomic sequence data indicate that some microorganisms, among them the Lyme disease pathogen, Borrelia burgdorferi, may not require iron, needing manganese instead for the metabolic and survival strategies they have evolved. Where competition for available iron exists, ability to get along without it can be a selective advantage, although a cell is capable of very few reactions, and no aerobic respiration.

Statistical Data Included, Carrier proteins, Transport proteins, Manganese, Bacterial genetics, Cells, Cell permeability, Virulence (Microbiology), Iron, Iron (Metal), Bacterial proteins, Homeostasis, Metal ions

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Moving folded proteins across the bacterial cell membrane

Article Abstract:

This article dwells upon the Tat protein export system mediating translocation of folded proteins across the cell membrane in bacteria. Research indicates that the Tat translocase moves structured macromolecular substrates of the Tat pathway, which are mainly folded proteins in association with cofactor molecules, across the bacterial cytoplasmic membrane.

Analysis, Biological transport, Structure-activity relationships (Biochemistry), Structure

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Direct evidence for mRNA binding and post-transcriptional regulation by Escherichia coli aconitases

Article Abstract:

Research was conducted to understand the regulatory role of Escherichia coli aconitases in modulating transcription-translation activities during oxidative stress. Results show synthesis of aconitases and cognate mRNAs increase in response to oxidative stress.

Methods, Enzymes, Protein synthesis, Genetic transcription, Transcription (Genetics), Messenger RNA, Enzyme regulation, Genetic translation, Translation (Genetics)

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