PPAR-gamma: an essential regulator of adipogenesis and modulator of fat cell function
Article Abstract:
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), an essential regulator of adipogenesis and a modulator of fat cell function, is discussed in this review article. Topics include adipogenic cell lines, gain-of-function and loss-of-function experiments, CCAAT/enhancer binding proteins (C/EBPs), and roles in fully differentiated mature adipocytes. TZD-mediated stimulation of PPAR-gamma helps insulin resistance. It appears that normal amounts of PPAR-gamma activity, under some circumstances, promote disease. Both its agonists and its antagonists might be useful clinically. Areas of interest for the future include the role of dietary fats as precursors to PPAR-gamma ligands.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Ribosomal mechanics, antibiotics, and GTP hydrolysis
Article Abstract:
Previous studies on bacterial ribosomes have established that L11-ribosomal RNA (rRNA) plays a key role in regulating ribosomal factor-dependent processes, including G proteins and GTPases activities. It was also found that GTPase-associated ribosomal site controls ribosomal factor binding and GTP hydrolysis by undergoing some conformational changes. The site has ben observed to be composed of two primary ribosomal components that include the protein-rRNA cluster and a pentameric L10(L12)4 complex.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
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