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PRDI-BFI/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins

Article Abstract:

PRDI-BFI/Blimp-1 repression is mediated by corepressors of the Groucho protein family. Likely corepressor complexes of the Groucho family proteins with DNA are necessary for the postinduction repression of the IFN-beta promoter. PRDI-BF1 represses transcription of the IFN-beta promoter and of an artificial promoter through an active repression mechanism. A minimal repression domain adequate for transcriptional repression when tethered to DNA as a Gal4 fusion protein has been identified in PRDI-BF1.

Genetic regulation, Genetic transcription, Transcription (Genetics), B cells, Cell differentiation

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A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedeghog signaling pathways

Article Abstract:

A ubiquitin ligase complex is essential for the Hedgehog, NF-kappa-B, and Wnt/Wingless signal paths. Ubiquitin-dependent proteolysis by the proteasome has an essential role in a number of key biological processes. Among them are signal transduction, cell cycle progression, and transcription. Discovery of the ubiquitin ligase complex for I-kappa-B-alpha is helpful to understanding of mechanisms of regulated proteolysis. New insight into signaling pathways of medical interest has been gained.

Genetic aspects, Observations, Cellular signal transduction, Ligases

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Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates

Article Abstract:

Research indicates that Groucho proteins play a significant role in DNA-binding transcription processes. Groucho proteins, or transcriptional corepressor proteins, are required for repression activities, but do not bind DNA alone. They are regulated by their DNA-binding partners or their own repressor process. More research is needed to determine how Groucho proteins repress both basal and activated transcription.

DNA, Eukaryotic cells, Cells (Biology), Eukaryotes, Proteins

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