Perspective: Machines for RNAi

Article Abstract:

The current understanding related to the production of small ribonucleic acid (RNAs), the process concerning their loading into the protein complexes and the repression of the gene expression is reviewed. Various issues related to RNAi silencing and RNAi machinery are detailed.

Gene expression, Protein research

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RISC is a 5' phosphomonoester-producing RNA endonuclease

Article Abstract:

Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). The mutational analysis of the target RNA, mismatches across from the 5' end of siRNA, and their effects are discussed.

Gene mutations, Gene mutation, Ribonucleoproteins

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Life beyond cleavage: The case of Ago2 and hematopoiesis

Article Abstract:

The article discusses the role and function of Ago2 for hematopoietic development as well as miRNA biogenesis.

Life, Messenger RNA, Hematopoiesis, Origin of life

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