Phagosome neutrality in host defense

Article Abstract:

The neutralization of phagosomal pH reduces protease activity and also improves crosspenetration in dendritic cells. The patients with chronic granulomatous disease have genetic defects in NADPH oxidase with about 65% lacking functional gp91 and the immunopathology of this condition extends beyond the deficiency in neutrophyll function to involve defects in antiviral T cell responses, most of which depend on class I MHC-restricted viral antigen crosspresentation.

Health aspects, Analysis, Genetic aspects, Proteolysis, Neutrophils, Chronic granulomatous disease

---

How the T cell receptor sees antigen - A structural view

Article Abstract:

The inherent reactivity of T cell receptors (TCR) for peptide- major histocompatibility complex (pMHC) is discussed. TCR possesses a particular orientation on the pMHC surface for placing the germline-encoded complementarity determining region-1 (CDR1) and complementarity determining region-1 (CDR2) loops in contact with the conserved helical residues of the MHC.

Major histocompatibility complex, Genetic research, Genetic code

---

The structure of the [zeta][zeta] transmembrane dimer reveals features essential for its assembly with the T cell receptor

Article Abstract:

The atomic-resolution NMR structure of the membrane-embedded portion of a critical signaling component of the T cell receptor (TCR)-CD3 complex, the [zeta][zeta] homodimer is presented. This structural unit representing only the second trans-membrane dimer interface serves as a paradigm for the assembly of all modules involved in TCR signaling.

Usage, Cell receptors, Nuclear magnetic resonance

Similar abstracts:

• Abstracts: Genetic neighbourhood of clone structures in eelgrass meadows quantified by spatial autocorrelation of microsatellite markers
• Abstracts: Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
• Abstracts: Crystal structure of mitochondrial respiratory membrane protein complex II. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
• Abstracts: Reduced genetic variation occurs among genes of the highly clonal plant pathogen Xanthomonas axonopodis pv. vesicatoria, including the effector gene avrBs2
• Abstracts: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.