Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

Article Abstract:

Studies to analyze and investigate the effect of pharmacologic disruption of polycomb-repressive complex-2 (PRC-2)-mediated gene repression on the silencing of cancer genes and cancer therapy are conducted. Analyses reveal that the reversal of PRC-2, when combined with hydrolase inhibitor 3-deazaneplanocin A (DZNep) can be used for cancer therapy, as it helps in killing of cancer cells.

Genetic aspects, Breast cancer, Cancer genetics, Clinical report

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TXR1-mediated thrombospondin repression: A novel mechanism of resistance to taxanes?

Article Abstract:

A new mechanism of taxane resistance involving protein TXR1 is described, which involves an important role for anti-angiogenic and proapoptotic protein thrombospondin -1 (TSP1). It is found that the result of taxane treatment is concentration-dependent and cell-type-specific, complicating the explanation of a single mechanism that underlies the cytotoxic response to drug treatment.

HEALTH SERVICES, Cancer Therapy, Ambulatory Health Care Services, Complications and side effects, Cancer treatment, Cell cycle

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