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Biological sciences

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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

Article Abstract:

A stable complex containing MLL1 and MOF proteins is immunoaffinity purified from a human cell line that stably expresses an epitope-tagged WDR5 subunit. Results indicate an activator-based mechanism for joint MLL1 and MOF recruitment and targeted methylation and acetylation along with a molecular explanation for the closely correlated distribution of Histone-H3 lysine-K4 methylation and H4 K16 acetylation on active genes.

Antigenic determinants

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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

Article Abstract:

A common component of MLL1, MLL2, and hSet1 human proteins H3 K4 methyltransferase complexes, the WD40-repeat protein WDR5, directly associates with histone H3 di- and trimethylated at K4 and with H3-K4-dimethlylated nucleosomes is demonstrated. Results show that a WD40-repeat protein acts as a modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation.

Epigenetic inheritance

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Taking LSD1 to a new high

Article Abstract:

A study revealed that LSD1, a nuclear amine oxidase homolog, is a bona fide histone H3 lysine 4 demethylase. Results suggest that LSD1's specificity and activity is in fact regulated by associated protein cofactors.

Histones, Gene expression, Cell proliferation, Lysine

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