Polarity determination in the Drosophila eye: a novel role for Unpaired and JAK/STAT signaling

Article Abstract:

A novel role has been seen for JAK/STAT signaling and Unpaired, a pathway ligand, in polarity determination in the developing Drosophila eye. Evidence from a new study shows that the JAK/STAT pathway is central for the development and that a localized source of Unpaired is at the midline of the developing eye. A gradient of the JAK/STAT activity across the dorsoventral axis of the eye regulates ommatidial polarity through an unknown signal. Localized Unpaired has an effect on the position of the equator by repressing mirror (ital). In Drosophila one JAK homolog encoded by the hopscotch (ital) locus and one STAT homolog, stat92E, have been identified.

United Kingdom, United States, Eye, Ligand binding (Biochemistry), Genetic research

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Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway

Article Abstract:

The unpaired (upd) gene has been characterized for Drosophila. The gene displays the same embryonic mutant defects as mutations in the Drosophila stat92E (STAT) and hopscotch (JAK) genes. Upd encodes a protein which is secreted and which activates the JAK signaling pathway. It is associated with the matrix outside the cell. Upd is proposed as a ligand that depends on JAK signaling to bring on transcription of pair-rule genes in a way that is segmentally restricted in the early embryo of Drosophila. Previously JAK and STAT molecules have been isolated, but ligands and receptors able to activate the pathway have not been described.

Analysis, Observations, Proteins, Ligands (Biochemistry), Protein kinases, Cell receptors

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Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila

Article Abstract:

A genome-wide RNA interference (RNAi) screen in cultured Drosophila cells was carried out to know how the Janus kinase/ signal transducer and activator of transcription (JAK/STAT) signaling participated in these diverse biological responses. Result revealed that the presence of many uncharacterized genes were responsible for different steps of the JAK/STAT signaling pathway.

Science & research, Genetic transcription, Transcription (Genetics), Cytokines, Chemical properties, RNA interference

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