Polybromo protein BAF180 functions in mammalian cardiac chamber maturation

Article Abstract:

The ablation of the mammalian chromatin remodeling complex, PBAF-specific subunit BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects, similar to those found in mice lacking nuclear receptors, RXRalpha and PPARgama. Embryonic aggregation analyses reveal that in contrast to PPARgama-deficient mice, the heart defects are likely result of BAF180 ablation, rather than an indirect consequence of trophoblast placental defects.

Chromatin, Protein binding, Genetic research

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Coactivator cross-talk specifies transcriptional output

Article Abstract:

The cell uses several classes of regulatory coactivator complexes including two central players, TFIID and Mediator (MED), in potentiating activated transcription. Robust response of the metallothionein genes to heavy metal is exploited as a model for transcriptional activation by analyzing direct factor recruitment in both heterogeneous cell populations and at the single level.

Metallothionein

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The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator

Article Abstract:

A stable complex containing the Evf-2 ncRNA and the Dlx-protein forms in vivo, suggesting that the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity. These experiments identify a novel mechanism whereby transcription is controlled by the cooperative actions of an ncRNA and a homeodomain protein.

United States, Physiological aspects, Genetic aspects, Brain

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