Polyglutamine neurodegenerative diseases and regulation of transcription: Assembling the puzzle

Article Abstract:

The role of the disease-causing polyglutamine proteins in gene transcription and the extent to which the mutant proteins induce disruption of transcription is reviewed. The polyglutamine disorders are a class of nine neuro-degenerative disorders that are inherited gain-of-function diseases caused by expansion of a translated CAG repeat.

United States, Genetic aspects, Nervous system, Neurodegenerative diseases

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Interaction between Sox 9 and beta-catenin control chondrocyte differentiation

Article Abstract:

The existence of physical and functional interactions between beta-catenin and Sox 9, a transcription factor that is required in successive steps of chondrogenesis is discussed. The results strongly suggest that chondrogenesis is controlled by interactions between Sox 9 and the Wnt / beta-catenin signaling pathway.

Genetic research

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RNA polymerase I transcriptional and pre-rRNA processing are linked by specific SSU processome components

Article Abstract:

Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal sub unit (SSU) processome if a large ribonucleoprotein (RNP) required for processing of precursors to the small sub unit RNA, the 1,8,S of the ribosome.

Ribosomal RNA, RNA polymerases, Ribonucleoproteins

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