Pushing back the expansion of introns in animal genomes

Article Abstract:

A survey of the position of introns in 30 genes of a marine annelid showed that over 60% of the introns occupy positions identical to those in human homologs, and in contrast, both human and marine annelid genes share only 30% of their introns with other invertebrates. These observations suggest that the common ancestor of most animal phyla had intron-rich genes and reinforce the notion that introns proliferated early in the evolutionary history of eukaryotes.

Genetic research, Introns

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UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex

Article Abstract:

Xeroderma pigmentosum group C (XPC) undergoes reversible ubiquitylation upon UV irradiation of cells and that this depends on the presence of functional UV-DBB activity. The results show that ubiquitylation plays a critical role in the transfer of the UV-induced lesion from UV-DDB to XPC.

DNA binding proteins, Xeroderma pigmentosum

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An unexpected role for ubiquitylation of a transcriptional activator

Article Abstract:

The roles of ubiquitylation and stability with respect to the function of the well-studied yeast activator Gal4 are explored. Gal4 has served as a paradigm for understanding how eukaryotic cells mount rapid transcriptional responses to environmental changes.

Genetic aspects, Yeast fungi, Yeasts (Fungi)

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