Ras promotes cell survival in Drosophila by downregulating hid expression
Article Abstract:
Decreased Dras1 function enhanced killing induced by the ectopic expression of the reaper and head involution defective (hid) genes in the developing Drosophila. It was observed that this antiapoptotic activity of increased Dras1 function is activated by the Drosophila homolog of the EGF receptor and uses the Raf/MAPK pathway. The Ras/MAPK pathway promoted cell survival in Drosophila by downregulating hid gene expression. These data indicated that one of the roles of the reticular activating system in normal development is to downregulate the proapoptotic activity of hid.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis
Article Abstract:
Fab-7 is a genetic regulatory element that modulates spatial transcription of the Abdominal-B gene in Drosophila embryos. Transgenic Drosophila lines with the Fab-7 regulatory element adjacent to a GAL4-driven lacZ reporter were used in the development of a system able to relieve the silencing function of Fab-7 during larval development. This derepressed state is inherited in a stable fashion during development and can be passed on to progenies.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
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