Perspectives on oxygen sensing
Article Abstract:
The physiological, medical, biochemical and genetic perspectives on oxygen sensing are described. Physiological studies have established that all mammals can sense changes in O2 concentration. From the medical point-of-view, the genetic and pharmacologic strategies to amplify adaptive responses to hypoxia in ischemic tissues and to inhibit these responses in cancer cells provide potential future therapies to various fatal disorders. Progress in biomechanical studies on oxygen sensing has been slow, but genetic approaches are slowly gaining grounds.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Xsox17alpha and -beta mediate endoderm formation in Xenopus
Article Abstract:
Two Xenopus relatives of murine Sox17 expressed in gastrula presumptive endoderm have been isolated. Ectopic expression of Xsox17alpha and -beta in animal caps leads to the expression of endoderm markers, which is blocked by overexpression of the Xsox17beta HMG domain to the Drosophila. The results indicate Xsox17 gene involvement in activin-induced endoderm differentiation pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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