Relationship of migrating luteinizing hormone-releasing hormone neurons to unique olfactory system glycoconjugates in embryonic rats

Article Abstract:

The migration of luteinizing hormone-releasing hormone (LHRH)-containing neurons across the cribiform plate to form a dispersed population in the mammalian basal forebrain was investigated. The findings demonstrate colocalization of unique glycoconjugate antigens on a subset of LHRH-immunoreactive (LHRHir) cell bodies and growth cones in the rostral forebrain during embryonic development in rats. Also, LHRHir neurons were found along CC2-immunoreactive fibers in the nasal activity, across the cribiform plate, and in the rostral forebrain.

Gonadotropin releasing hormone, Gonadorelin, Antigens

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Neurite branch development of an identified serotonergic neuron from embryonic Helisoma: evidence for autoregulation by serotonin

Article Abstract:

Experimental studies on embryonic neurons C1 (ENC1) from Helisoma trivolvis reveal that neurite formation during embryonic development is regulated by serotonin in an autoregulatory fashion. Initial outgrowth of primary neurites is not influenced by p-chlorophenylalanine (pCPA) and 5-hydroxytryptophan (5-HTP). Neurite branching is increased and decreased, respectively, by pCPA and 5-HTP. Embryonic serotonin level is increased upon adding 5-HTP.

Analysis, Physiological aspects, Metabolic regulation, Growth, Growth (Physiology), Growth regulators, Embryology, Animal embryology, Serotonin

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Embryonic stem cells express neuronal properties in vitro

Article Abstract:

Embryonic stem cells can be grown in culture so they differentiate into cells resembling neurons. Retinoic acid is necessary for their complete differentiation. These neuron-like cells exhibit many of the properties of neurons, including action potentials, TTX-sensitive sodium channels, voltage-gated potassium channels and calcium channels. They also express the M subunit of neurofilament and class III beta-tubulin.

Mice, Mice (Rodents), Stem cells

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