Cytotoxicity associated with trichloroethylene oxidation in Burkholderia cepacia G4
Article Abstract:
Trichloroethylene (TCE) oxidation by Burkholderia cepacia G4 is toxic to the bacterium. This occurs because reactive intermediates generated during TCE oxidation can inactivate not only the oxygenase, but also other cellular constituents as well.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2001
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Requirement of DNA repair mechanisms for survival of Burkholderia cepacia G4 upon degradation of trichloroethylene
Article Abstract:
Burkholderia cepacia G4 can degrade trichloroethylene (TCE) as long as its DNA repair mechanism is intact. This bacterium is more resistant to the toxic effects of TCE than other bacteria and for this reason is considered a potential agent for TCE biodegradation.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2001
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Inactivation of toluene 2-monooxygenase in Burkholderia cepacia G4 by alkynes
Article Abstract:
Research was conducted to examine the inactivation of toluene 2-monooxygenase in Burkholderia cepacia G4 by alkynes. Results demonstrate that different alkynes serve as potent inhibitors of the toluene-dependent growth of B. cepacia. Findings also reveal that toluene 2-monooxygenase activity is specifically inactivated by the compounds. Therefore, alkynes represent a general class of mechanism-based inactivators for toluene 2-monooxygenase activity in B. cepacia G4.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1999
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