Secreted fringe-like signaling molecules maybe glycosyltransferases

Article Abstract:

Signaling molecules involved in pattern formation, such as Drosophila Fringe and Drosophila Brainiac, may be secreted glycosyltansferases. This is not completely unexpected since glycosyltransferases have long been associated with developmental processes, several glycosyltransferases have been found in humans and the chances of the expression of highly expressed glycosyltransferases increase during embryonic development. Secreted glycosyltransferases may even play a major role in epithelial pattern formation.

Transferases, Letter to the Editor

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

Article Abstract:

Researchers have identified a novel secreted glycoprotein that regulates bone resorption. The protein, designated Osteoprotegerin (OPG), belongs to the TNF receptor superfamily. The findings suggest that OPG can function as a soluble factor in bone mass regulation. The results also imply that potential importance of OPG in the treatment of osteoporosis associated with increased osteoclast activity.

Care and treatment, Glycoproteins, Bone resorption, Osteoporosis

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Embryonic dorsal-ventral signaling: Secreted Frizzled-related proteins as inhibitors of Tolloid Proteinases

Article Abstract:

An unexpected role for the secreted Frizzled-related protein (sFRP) Sizzled/Ogon as an inhibitor of the extra-cellular proteolytic reaction that control Bone Morphogenetic Protein (BMP) signaling during Xenopus gastrulation is studied. Sizzled is a natural inhibitor of BMP1, a Tolloid metalloproteinase of medical interest.

United States, Metalloproteins, Bone morphogenetic proteins, Chemical properties

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