Signal sequences: the same yet different

Article Abstract:

An increasing number of studies dispel the traditional concept of a similar coding mechanism in signal sequencing, which occurs among procaryotes and eukaryotes alike. More recent reports reveal a signal sequence-dependent specific targeting of proteins. Signal sequences also play varied molecular roles. Most of these findings were discovered with Saccharomyces cerevisiae. Two Walter laboratory studies, for example, provide new information on pathway preferences of signal sequences.

Saccharomyces, Signal peptides

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Are ubiquitination pathways central to Parkinson's disease?

Article Abstract:

This review examines the physiological changes and biochemical pathways governing the etiology of parkinson's disease. Research findings implicate the involvement of alterations or reductions in ubiquitin-mediated proteasome function in the manifestation of some forms of parkinsonism in terms of dopaminergic neuron degeneration.

Influence, Neurons, Parkinson's disease, Parkinson disease, Degeneration (Pathology)

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

Article Abstract:

The crystal structure of a c-Cbl-UbcH7-ZAP70 peptide ternary complex reveals the rigid coupling between the peptide binding and the ubiquitin-conjugating enzyme binding domains. Results further show that RING domain of the c-Cbl proto-oncogene aids in positioning the substrate and the enzyme for ubiquitin transfer.

Statistical Data Included, Analysis, Proteins, Cellular signal transduction, Proto-oncogenes, Protein denaturation, Cooperative binding (Biochemistry)

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