Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

Article Abstract:

The hematopoietic system as a model is used to investigate whether acute myeloid leukemia arises exclusively from self-renewing stem cells or also from short-lived myeloid progenitors. The findings show the ability of transient repopulation progenitors to initiate myeloid leukemia in response to an MLL oncogene, and support the existence of cancer stem cells that do not necessarily overlap with multipotent stem cells of the tissue of origin.

Usage, Causes of, Acute myelocytic leukemia, Progeria, Hematopoietic system

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JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells

Article Abstract:

The AP-1 transcription factor JunB regulates the numbers of hematopoietic stem cells (HSC). JunB overexpression decreases the frequency of long-term HSC, while JunB inactivation specifically expands the number of long term HSC and granulocyte/macrophage progenitors resulting in chronic myeloproliferative disorder (MPD).

Hematopoietic stem cells, Granulocytes, Myeloproliferative disorders

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Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell protein

Article Abstract:

A study is conducted on the dominant-negative genetic techniques to investigate the requirements and contributions of three-amino-acid loop extension class home domain proteins of the Pbx and Meis families in MLL oncoprotein-induced acute myeloid leukemia.

Genetic aspects, Mutation (Biology), Mutation, Stem cells, Leukemia, Amino acids

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