Sir-Ku-itous routes to make ends meet

Article Abstract:

A study was conducted to better understand how the Ku and Sir proteins are involved in the normal telomere function and structure, prevention of end-to-end fusions and implicated in the end fusion process. Experiments with the Saccharomyces cerevisiae reveal that the Ku and Sir proteins at the telomeres tend to relocalize away from the subtelomeric regions and diffuse themselves all over the nucleus in the presence of DNA damage.

Telomeres, Proteins, Saccharomyces

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Solution structure of the CIDE-N domain of CIDE-B and a model of CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis

Article Abstract:

Results describe the structure of CIDE-N of human CIDE-B protein and show its interaction with CIDE-N domains of both 40 kDA capsule-activated DNA fragmentation factor (DFF40) and the inhibitor DFF45. Role of this novel bipolar interaction in the regulation of downstream events of apoptosis is discussed.

United States, Singapore, Research, Analysis, Cell death, Crystallography

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Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair

Article Abstract:

Binding of isositol phosphate to DNA-PK is discussed, consideration of stimulation of double-strand break repair.

United Kingdom, Statistical Data Included, Inositol phosphates

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