Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo
Article Abstract:
The exact identity of the lipids as well as molecules derived from these lipids, which can modulate TRP cation channel activity, are unknown to researchers. Tests were conducted using genetic as well as behavioral analysis to know more about the identity, which showed that a subset of 20-carbon polyunsaturated fatty acids with omega-3 and omega-6 acyl groups act as endogenous modulators of TRPV signal transduction.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Using isoform-specific inhibitors to target lipid kinases
Article Abstract:
A detailed pharmocological analysis of the PI3 kinase family is presented using small molecule inhibitors. It is concluded that p110(alpha), a P13-K isoform, has a critical role in insulin signaling.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans
Article Abstract:
Sterility effects of di hommo gamma-linolenic acid on germ cells of C. elegans are presented.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Intrinsically unstructured proteins evolve by repeat expansion. Speciation and inversions: chimps and humans
- Abstracts: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Hsp70 promotes TNF-mediated apoptosis by binding IKKgamma and impairing NF-kappaB survival signaling
- Abstracts: Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling
- Abstracts: Cargo regulates clathrin-coated pit dynamics. Advocating asymmetry and the POP-1 paradox: Noncanonical Wnt signaling in C. elegans
- Abstracts: The CBF(beta) subunit is essential for CBF(alpha)2 (AML1) function in vivo