Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization

Article Abstract:

The molecular basis of vascular stabilization regulated by sphingosine 1-phosphate (S1P), a platelet-derived lipid mediator is investigated. S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases.

Sphingosine

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The PTEN/P13K pathway governs normal vascular development and tumor angiogenesis

Article Abstract:

Study is conducted in which Cre-loxP system was used to generate an endothelial cell-specific mutation of Pten(Tie2CrePten) in mice. Tie2CrePten(sub flox/+) mice showed enhanced tumorigenesis due to increase in angiogenesis driven by vascular growth factors, which was partially dependent on P13K subunits p85alpha and p110gamma.

Japan, Health aspects, Analysis, Tumor suppressor genes, Rats, Structure, Rattus, Apoptosis, Tumour suppressor genes

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A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging

Article Abstract:

Coregulator DIN-1 and DAF-12 is shown interacting physically and genetically to instruct organismal fates. It is proposed that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals.

Canada, Lipid metabolism

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