Wilms' tumor 1 and dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

Article Abstract:

The gene expression of the polypeptide hormone Mullerian inhibiting substance (MIS) is promoted by the synergy between steroidogenic factor 1 (SF-1) genes and Wilms' tumor 1 (WT1)-KTS isoforms. However, this reaction is antagonized by the sex-reversal gene Dax-1. Moreover, the SF-1 gene does not synergize with WT1 missense mutations. The conflict between Dax-1 and WT1 is achieved by modulating SF-1-mediated transactivation.

Genetic aspects, Sex determination, Genetic, Sex determination (Genetics), Testis-determining factor

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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors Sf-1 and LRH-1

Article Abstract:

Structural and biochemical data for three NR5A members, mouse and human SF-1 and human LRH-1, is presented. It is revealed that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity.

Industrial Organic Chemicals, Cyclic Crude and Intermediate Manufacturing, Inositol

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Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors Sf-1 and LRH-1

Article Abstract:

Structural and biochemical data for three NR5A members, mouse and human SF-1 and human LRH-1, is presented. It is revealed that these receptors bind phosphatidyl inositol second messengers and that ligand binding is required for maximal activity.

Analysis, Phosphatidylinositol, Phosphatidylinositols

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