Structural features of the glutamate transporter family

Article Abstract:

Neuronal and glial glutamate transporters remove the excitatory neurotransmitter glutamate from the synaptic cleft. The proteins belong to a large family of secondary transporters that include serine, bacterial glutamate and C4-dicarboxylate transporters. Moreover, the homology between family members is the most significant in a stretch of about 150 residues in the C-terminal portion of the proteins.

Analysis, Proteins, Glutamate

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The 2-hydroxycarboxylate transporter family: Physiology, structure, and mechanism

Article Abstract:

The knowledge about the 2-hydroxycarboxylate transporter (2HCT) family, a family of secondary transporters is reviewed. Transporters of the 2HCT family are found exclusively in the bacterial kingdom, predominantly in the class Bacillales of the phylum Firmicutes and the beta and gamma subdivisions of the phylum Protebacteria, where they function in the specific niches.

United States, Physiological aspects, Genetic aspects, Bacillaceae, Protea

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Membrane topology and insertion of membrane proteins: search for topogenic signals

Article Abstract:

Biochemical methods for determining membrane protein topology and insertion are described. Understanding the mechanisms of insertion will allow scientists to predict the three-dimensional structure of the protein from its amino acid sequence.

Research, Membrane proteins, Lipid membranes, Bilayer lipid membranes

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