Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily

Article Abstract:

Research was conducted to solve the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A complex at 2.3 A resolution. Results revealed the elongated and curved structure of Hat1 while the AcCoa molecule is bound in a cleft on the concave surface of the protein. The structure of Hat1 may be used as a model for identifying the structures of the catalytic domains of other histone acetyltransferases such as Gcn5 and CBP.

Chemical structure

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It takes a PHD to read the histone code

Article Abstract:

Plant homeodomain (PHD) finger protein is a highly specialized methyl-lysine binding domain that is found in a variety of proteins and it is used to read the pattern of histone modifications, called the histone code. The PHD finger is found to promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.

Science & research, Homeobox genes

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ROR[alpha]-mediated Purkinje cell development determines disease severity in adult SCA1 mice

Article Abstract:

A conditional transgenic mouse model of spinocerebellar ataxia type 1 (SCA1) is used to delay the postnatal expression of mutant ATXN1 until after completion of cerebellar development in order to examine the effect of development on SCA1. The analysis has shown that a decrease of ROR[alpha]-mediated gene expression during development is a key factor in the susceptibility of Purkinje cells to SCA1.

Genetic aspects, Genetic research, Purkinje cells, Spinocerebellar ataxia

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