Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis

Article Abstract:

The authors dicuss the role of the nuclear bile acid receptor FXR/BAR as an intracellular bile acide sensor in lipid and bile accid homeostasis.

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Combinatorial roles of the nuclear receptor corepressor in transcription and development

Article Abstract:

Findings of a recent study of metazoan development suggest that specific combinations of histone deacetylases and corepressors mediate the gene-specific actions of DNA-bound repressors in multiple organ system development. It was found, surprisingly, that N-coR and a specific deacetylase were required for transcriptional activation of one class of retinoic acid response element.

Histones, Embryology, Experimental, Embryological research, Metazoa, Metazoans, Cell differentiation, Estrogen, Estrogens, Progesterone

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'Don't know much bile-ology'

Article Abstract:

Recently published work that establishes a specific role for the nuclear receptor FXR in cholesterol catabolism pathways and in repression of the CYP7A1 gene and regulation by nuclear receptors, is discussed in this review article. The rate-limiting step of the neutral bile biosynthesis pathway is catalyzed by the cytochrome P450 cholesterol 7alpha-hydroxylase or CYP7A1. Lipid homeostasis in vertebrates, that is, the acquisition, synthesis and metabolism of cholesterol, is important. As mediators of organ physiology, nuclear hormone receptors, and other proteins are thought to play a vital role in the processes by controlling the transcription of genes encoding the transporters, the apoplipoproteins, as well as catabolic and synthetic enzymes. Implications for future drug development in treatment of hypercholesterolemia and cholestasis are important.

Liver, Apolipoproteins, Vertebrates, Lipid metabolism, Cholesterol, Homeostasis

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