The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center
Article Abstract:
RNA fluorescence in situ hybridization (RNA-FISH) together with protein immunolocalization is used to present evidence for the Arabidopsis chromatin-modifying small interfering RNS (siRNA) processing centers associated with nucleolus. The results have shown that maintenance of the heterochromatic state involves locus-specific nuclear RNA polymerase IV (Pol IVa) transcription followed by siRNA production and assembly of ARGONAUTE4 (AGO-4) and the largest-subunit genes (NRPD1b)-containing silencing complexes within nucleolar processing centers.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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VIM1, a methylcytosine-binding protein required for centromeric heterochromatinization
Article Abstract:
The research focuses on variant in methylation 1(VIM1), an unconventional methylcytosine-binding protein containing several domains of mammalian proteins, which are then used in the regulation of chromatin modification, transcription and the cell cycle. The results reveal that VIM1 is highly enriched in chromocenters and hence acts as the DNA methylation-histone interface for maintaining centromeric heterochromatin.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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