Abstracts - faqs.org

Abstracts

Biological sciences

Search abstracts:
Abstracts » Biological sciences

The C terminus of the L-type voltage-gated calcium channel [Ca.sub.v]1.2 encodes a transcription factor

Article Abstract:

The C-terminal fragment of [Ca.sub.v]1.2, an L-type voltage-gated calcium channel (LTC), associated transcription regulator (CCAT) binds to a nuclear protein, associates with an endogenous promoter and regulates the expression of a wide variety of endogeneous genes important for neuronal signaling and excitability. The results have provided evidence that voltage-gated calcium channels can directly activate transcription and have described a mechanism linking voltage-gated channels to the function and differentiation of excitable cells.

Author: Hu, Linda, Gomez-Ospina, Natalia, Tsuruta, Fuminori, Barreto-Chang, Odmara, Dolmetsch, Ricardo
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Calcium channels

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

Article Abstract:

A genome-wide screen was carried out to identify GATA-3 as the most highly enriched transcription factor in the mammary ductal epithelium of pubertal mice and show that GATA-3 is localized to the body cells of terminal end buds (TEBs) and to the mature luminal cells of mammary ducts. The findings suggest that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer.

Author: Werb, Zena, Kouros-Mehr, Hosein, Slorach, Euan M., Sternlicht, Mark D.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Cell differentiation

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Re-evaluating cell-cycle regulation by E2Fs

Article Abstract:

An alternative model of the activation of E2F transcription factors, which is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication, is presented. The findings suggest that E2Fs establish a link between the cell cycle and either cell-extrinsic or cell-intrinsic factors involved in cell-cycle regulation that might be either pro- or antimitogenic.

Author: Rowland, Benjamin D., Bernnards, Rene
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Cell cycle, DNA replication

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Cellular control mechanisms, Cell regulation, DNA binding proteins, Structure, Chemical properties, Report
Similar abstracts:
  • Abstracts: Control of cell lineage-specific development and transcription by bHLH-PAS proteins. Spineless provides a little backbone for dendritic morphogenesis
  • Abstracts: A protein of the sea urchin cortical granules is targeted to the fertilization envelope and contains an LDL-receptor-like motif
  • Abstracts: Development and function of the mammalian spleen. Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
  • Abstracts: The BRCA1/BARD1 heterodimer modulates Ran-development mitotic spindle assembly. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2022 Advameg, Inc.