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The Candida albicans antiporter gene CNH1 has a role in Na+ and H+ transport, salt tolerance, and morphogenesis

Article Abstract:

The Candida albicans antiporter gene CNH1 has a role in salt tolerance, H+ and Na+ transport, and morphogenesis. Isolation and functional characterization of the gene, which encodes a protein of 840 amino acids that show high levels of similarity in size sequence, and structural and functional domains to a group of known Na/H antiporters of fungi has been carried out. The CNH1 gene can complement the function of the salt-sensitivity of a Saccharomyces cerevisiae ena1 nha1 mutant. Mutations of two conserved aspartate residues to asparagines in the putative Na+-binding site stop the activity.

Singapore, DNA damage, Sodium, Sodium (Chemical element), Salt-tolerant crops, Hydrogen-ion concentration

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A Candida albicans chaperonin subunit (CaCct8p) as a suppressor of morphogenesis and Ras phenotypes in C. albicans and Saccharomyces cerevisiae

Article Abstract:

Research was conducted to examine the hypothesis that Saccharomyces cerevisiae and the pathogen Candida albicans can be induced to undergo morphogenesis from a yeast to a filamentous form. Results indicated that overexpression of CaCCT8, encoding subunit 8 of the Cct chaperonin complex, inhibits hyphal morphogenesis in C albicans. Findings also showed that its expression in the heterologous host S cerevisiae blocks pseudohyphal growth.

Bacterial growth, Phenotype, Phenotypes, Saccharomyces, Ras genes

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Transcription factors in Candida albicans-environmental control of morphogenesis

Article Abstract:

Research reveals that the Candida albicans's dimorphism is a dominant virulence factor and its relationship to the environmental cues such as sources of serum, nitrogen starvation, neutral pH, temperature and cell density influence its transcription factors triggering the key elements of morphogenesis.

United States, Germany, Environmental aspects, Cellular signal transduction, Genetic transcription, Transcription (Genetics), Dimorphism (Biology), Dimorphism (Plants)

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