Abstracts

Biological sciences

Search abstracts:

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Article Abstract:

The RNA interference against ATM inhibited accumulation in cells, which expresses oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence, is reported. It is observed that bypassing oncogene-induced senescence by inactivation of p53 and Rb did not eliminate the accumulation of oncogene-induced DNA damage loci, thereby suggesting a mechanism that may limit transformation in immortalized cells.

Aging, Aging (Biology), RNA interference

---

Poly(ADP-ribosyl)ation by PARP-1: 'Par-laying' NAD+ into a nuclear signal

Article Abstract:

Recent work on the biochemistry, biology, physiology and pathophysiology of poly(ADP-ribosyl)ation (PARylation) focusing the activity of poly(ADP-ribose) polymerase 1(PARP-1), the most abundantly expressed member of a family of PARP proteins is highlighted. Also, connections between nuclear nicotinamide adenine denucleotide (NAD(super +)) metabolism and nuclear signaling through PARP-1 is discussed.

New York, RNA polymerases, Structure

---

RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress induced p21 transcript

Article Abstract:

A study presents evidence that the RNPC1 gene is induced by the p53 family and by DNA damage in a p53-dependent manner. It is also shown that RNPC1 is required for the maintenance of the stability of p21 transcript induced by p53 and it is concluded that RNPC1 is a target of the p53 family and serves as a mediator of the p53 family to regulate p21 post-transcriptionally.

Similar abstracts:

• Abstracts: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
• Abstracts: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
• Abstracts: Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. No rest for REST: REST/NRSF regulation of neurogenesis
• Abstracts: Kash 'n karry: The KASH domain family of cargo-specific cytoskeletal adaptor proteins. ALIX-ing phospholipids with endosome biogenesis
• Abstracts: Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction. Gas1 extends the range of Hedgehog action by facilitating its signaling

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.