The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

Article Abstract:

A Drosophila Activin receptor, Baboon, signals using dSmad2 and controls cell proliferation but larval development patterning. The role of Baboon (Babo), a type I Activin receptor called Atr-I in the past, in Drosophila development has been described. Aspects of the Babo intracellular signal-transduction pathway have been characterized. A new Drosophila Smad has been identified. It is called dSmad2 and is closely related to vertebrate Smads 2 and 3. A novel Drosophila Activin/TGF-beta pathway has been defined and is analogous to the vertebrate counterpart.

United States, Canada, Genetic aspects, Proteins, Genetic regulation, Eye, Drosophila, Cell receptors, Cell proliferation, Larvae

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Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity in the early mouse embryo

Article Abstract:

Research was conducted to study Smad2 mutant embryos developed using ES cell technology. Embryos were dissected free of maternal tissues while heterozygous Smad2 mice were crossed to animals with the nodal.LacZ allele. Results showed that the loss of Smad2 activity disturbed the development of the primitive endoderm lineage. They also showed the presence of Bmp4 transcripts in the marginal zone between the animal and vegetal hemispheres.

Physiological aspects, Mice, Mice (Rodents), Embryology, Animal embryology

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