The Evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor Emi1

Article Abstract:

Evi5 functions as a stabilizing factor maintaining Emi1 levels in S/G2 phase where Evi5 protein accumulates in early G1 following Plk1 destruction and is degraded in a plk1- and ubiquitin-dependent manner in early mitosis. It is proposed that the balance of Evi5 and Pololike kinase activities determines the timely accumulation of Emi1 and cyclin, ensuring miltotic fidelity.

Science & research, Eukaryotes, Protein research

---

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

Article Abstract:

This article reports the discovery of an early mitotic inhibitor, Emi1, which is involved in the regulation of cell division via anaphase promoting complex/cyclosome (APC) inhibition. Data indicate that Emi1 stabilizes APC substrates leading to mitotic block, while APC inhibiton by its activator Cdc20 restores Emi1-induced block.

Austria, Xenopus, Enzyme inhibitors

---

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

Article Abstract:

Emi1 has been found to regulate the anaphase-promoting complex by a mechanism different from Mad2 proteins. Emi1 bonds the substrate binding region of Cdc20 and prevents substrate binding to the anaphase-promoting complex/cyclosome.

Statistical Data Included, Cytochemistry, Ubiquitin, Anaphase

Similar abstracts:

• Abstracts: Regulation of translation initiation by FRAP/mTOR. Hierarchical phosphorylation of the translation inhibitor 4E-BP1
• Abstracts: Role of methanogens and other bacteria in degradation of dimethyl sulfide and methanethiol in anoxic freshwater sediments
• Abstracts: Genetic differentiation of oak populations within Quercus robur/Quercus petraea complex in Central and Eastern Europe
• Abstracts: Development and characterization of DNA sequence OmyP9 associated with the sex chromosomes in rainbow trout. Sperm development, age and sex chromosome meiotic drive in the stalk-eyed fly, Cyrtodiopsis whitei
• Abstracts: Evolution of genetic variability in a population of the edible snail, Helix aspersa Muller, undergoing domestication and short-term selection

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.