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The Evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor Emi1

Article Abstract:

Evi5 functions as a stabilizing factor maintaining Emi1 levels in S/G2 phase where Evi5 protein accumulates in early G1 following Plk1 destruction and is degraded in a plk1- and ubiquitin-dependent manner in early mitosis. It is proposed that the balance of Evi5 and Pololike kinase activities determines the timely accumulation of Emi1 and cyclin, ensuring miltotic fidelity.

Author: Reimann, Julie D.R., Jackson, Peter K., Eldridgem Adam G., Loktev, Alexander V., Hansen, David V., Verschuren, Emmy W.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Science & research, Eukaryotes, Protein research

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Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

Article Abstract:

This article reports the discovery of an early mitotic inhibitor, Emi1, which is involved in the regulation of cell division via anaphase promoting complex/cyclosome (APC) inhibition. Data indicate that Emi1 stabilizes APC substrates leading to mitotic block, while APC inhibiton by its activator Cdc20 restores Emi1-induced block.

Author: Kramer, Edgar R., Peters, Jan-Michael, Reimann, Julie D.R., Freed, Ellen, Hsu, Jerry Y., Jackson, Peter K.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Austria, Xenopus, Enzyme inhibitors

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Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

Article Abstract:

Emi1 has been found to regulate the anaphase-promoting complex by a mechanism different from Mad2 proteins. Emi1 bonds the substrate binding region of Cdc20 and prevents substrate binding to the anaphase-promoting complex/cyclosome.

Author: Reimann, Julie D.R., Jackson, Peter K., Gardner, Bryan E., Margottin-Goguet, Florence
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
Statistical Data Included, Cytochemistry, Ubiquitin, Anaphase

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Subjects list: Research, United States, Physiological aspects, Cell cycle, Mitosis
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