Ending the message is not so simple
Article Abstract:
Evidence indicates that the 3' ends of mRNA experience a significant degree of regulated gene expression. Several genes have been observed to use alternate poly(A) signals in 3' untranslated regions. Molecular geneticists often define mRNA 3' ends only through cDNA cloning or RT-PCR, reflecting the lack of knowledge of the complete mechanics of gene regulation. More complete sequence data have to be obtained to understand the mechanics of alternative polyadenylation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
Article Abstract:
The human FHIT gene which belongs to the histidine triad gene family and encodes a protein with 69% likeness to an S. pombe enzyme, diadenosine 5',5''' P1, P4-tetraphosphate asymmetrical hydrolase, was detected. The FHIT locus contains 10 exons spread over at least 500 kb, with three 5' untranslated exons contromeric to the renal carcinoma. Defective transcripts of the FHIT locus were discovered in about half of esophageal, stomach and colon cancer cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
User Contributions:
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