The Wilms' tumor 1 (WT1) gene (KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron

Article Abstract:

Study conducted reveals that the Wilms' tumor 1 WT1(KTS) functions to enhance expression from RNA possessing a retained intron and containing either a cellular or viral constitutive transport element (CTE) is shown. WT1(KTS) expression increases the levels of unspliced RNA containing a CTE and specifically promotes the association of this RNA with polyribosomes.

Genetic regulation, RNA, Nephroblastoma

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A novel cell-to-cell trafficking assay indicates that the KNOX homeodomain is necessary and sufficient for intercellular protein and mRNA trafficking

Article Abstract:

A novel cell-to-cell trafficking assay is developed by using trichome rescue in Arabidopsis. The studies show that the KNOX homeodomain (HD) is necessary and sufficient for intercellular trafficking, identifying a novel function for the HD as the minimal sequence required for trafficking of KN1 and its associated mRNA.

United States, Nucleotide sequence, Base sequence, Arabidopsis thaliana

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Tap and NXT promote translation of unspliced mRNA

Article Abstract:

Tap and NXT proteins function together to enhance translation of proteins from the exported constitutive transport element (CTE) RNA. Pulse chase experiments reveal that Tap/NXT significantly increases the rate of protein synthesis.

Methods, Protein synthesis, Protein biosynthesis

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