The Wilms' tumor 1 (WT1) gene (KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
Article Abstract:
Study conducted reveals that the Wilms' tumor 1 WT1(KTS) functions to enhance expression from RNA possessing a retained intron and containing either a cellular or viral constitutive transport element (CTE) is shown. WT1(KTS) expression increases the levels of unspliced RNA containing a CTE and specifically promotes the association of this RNA with polyribosomes.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A novel cell-to-cell trafficking assay indicates that the KNOX homeodomain is necessary and sufficient for intercellular protein and mRNA trafficking
Article Abstract:
A novel cell-to-cell trafficking assay is developed by using trichome rescue in Arabidopsis. The studies show that the KNOX homeodomain (HD) is necessary and sufficient for intercellular trafficking, identifying a novel function for the HD as the minimal sequence required for trafficking of KN1 and its associated mRNA.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Tap and NXT promote translation of unspliced mRNA
Article Abstract:
Tap and NXT proteins function together to enhance translation of proteins from the exported constitutive transport element (CTE) RNA. Pulse chase experiments reveal that Tap/NXT significantly increases the rate of protein synthesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation
- Abstracts: Genetic studies of mei-1 gene activity during the transition from meiosis to mitosis in Caenorhabditis elegans
- Abstracts: The distribution of spontaneous mutations on quantitative traits and fitness in Drosophila melanogaster. Effective size of populations under selection
- Abstracts: RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus. The DExH box protein Suv3p is a component of a yeast mitochondrial 3'-to-5' exoribonuclease that suppresses group I intron toxicity
- Abstracts: Bacterial transformations of 1,2,3,4-tetrahydrodibenzothiophene and dibenzothiophene. Use of fluorinated compounds to detect aromatic metabolites from m-cresol in a methanogenic consortium: evidence for a demethylation reaction