The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium

Article Abstract:

The impact of degree of linkage disequilibrium (LD), marker allele frequency, and association type have on estimating the probabilities of sharing alleles identical by descent in multipoint calculations and hence on type I error rates different sib-pair linkage approaches that assume linkage equilibrium (LE) is investigated. The affected sib pair/discordant sib pairs (ASP/DSP) design with appropriate sib-pair statistics is advocated for testing the difference in allele sharing between ASPs and DSPs.

Genetic markers, Genetic research

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Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes

Article Abstract:

The application and the accuracy of using the optimal receiver operating characteristic curve for designing a predictive genetic test for different diseases, like the type 2 diabetes is explained. The described approach is found to be highly cheap and accurate, as compared to the existing technologies.

Usage, Diagnosis, Bayesian statistical decision theory, Bayesian analysis, Genetic aspects, Type 2 diabetes, Genetic screening, Genetic testing

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Improved power by use of a weighted score test for linkage disequilibrium mapping

Article Abstract:

A new weighted score statistic is developed based on Fourier transform coefficients to globally test a set of correlated single-nucleotide polymorphism (tSNPs). This method can be used for discrete or continuous traits as these simulations demonstrate its substantially higher power.

United States, Single nucleotide polymorphisms

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